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X-WR-CALDESC:Events for Plant Proteoform Diversity
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DTSTART;TZID=Europe/Berlin:20251118T170000
DTEND;TZID=Europe/Berlin:20251118T183000
DTSTAMP:20260506T104235
CREATED:20250911T113557Z
LAST-MODIFIED:20251014T074333Z
UID:2109-1763485200-1763490600@snp2prot.uni-halle.de
SUMMARY:Colloquium with Anne Claire Conibear (TU Wien\, Austria)
DESCRIPTION:On 18 November 2025\, Anne Claire Conibear (TU Wien\, Austria) will present insights to her current research as part of the SNP2Prot Colloquium Series. \n\nSpeaker: Anne Claire Conibear (TU Wien\, Austria)\nTitle: Posttranslational Modifications of Disordered Proteins \nDate: Tuesday\, 18 November 2025\nTime: 5 pm\nLocation: Lecture hall E.02\, Theodor-Lieser-Strasse 9 (Heide Süd Campus)\, 06120 Halle (Saale) \n\nAbstract: The conformational flexibility of intrinsically disordered proteins and protein regions (IDRs)\, and their accessibility to modifying enzymes make IDRs hot-spots for protein regulation by posttranslational modifications (PTMs). Such PTMs increase the complexity of the proteome and can have central roles in regulating protein function\, location\, interactions and degradation. Little is known\, however\, about how PTMs modulate the conformations and interactions of IDRs\, as they typically occupy multiple conformational states\, have promiscuous interactions\, and are often removed or poorly represented in structural biology studies. In this presentation\, I will discuss our work towards understanding how PTMs modulate the conformations and interactions of IDRs. Protein synthesis and semi-synthesis provides access to site-specifically modified variants of IDRs\, such as the HMGN1 and Tau proteins\, and disordered termini of Hsp90 and β-catenin. These protein variants enable us to study the precise effects of PTMs and cross-talk of multiple PTMs on conformational populations using NMR spectroscopy. With these examples\, I aim to show how integrating chemical protein synthesis with structural biology of IDRs allows us to gain new insights into the effects of PTMs on the conformation\, dynamics and regulation of IDRs. \nReferences:\n[1] Conibear\, A. C.\, Nat. Rev. Chem. 4\, 674-695 (2020).\n[2] Niederacher\, G.\, Urwin\, D.; Dijkwel\, Y.\, Tremethick\, D. J.\, Rosengren\, K. J.\, Becker\, C. F. W.\, Conibear\, A. C.\, RSC Chem. Biol. 2\, 537-550 (2021).\n[3] Iebed\, D.\, Gökler\, T.\, van Ingen\, H.\, Conibear\, A. C.\, ChemBioChem\, 25\, e20241023 (2024).\n[4] Gajsek\, O.\, Becker\, C. F. W.\, Conibear\, A. C.\, Chem. Eur. J. e202403676 (2024). \n\nIf you like to meet with the speaker\, please contact the host\, Clara Schoeder (Uni Leipzig). \n\nSee all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/ \nThe SNP2Prot Colloquium Series is integrated to the \n\nHalle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/\nIPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare\n\n\n\n\n 
URL:https://snp2prot.uni-halle.de/event/colloquium-with-anne-claire-conibear-tu-wien-austria/
LOCATION:Lecture hall E.02 (Heide Süd Campus)\, Theodor-Lieser-Strasse 9\, Halle (Saale)\, 06120
CATEGORIES:SNP2Prot Colloquia
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DTSTART;TZID=Europe/Berlin:20251125T170000
DTEND;TZID=Europe/Berlin:20251125T183000
DTSTAMP:20260506T104235
CREATED:20250509T090635Z
LAST-MODIFIED:20251124T092856Z
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SUMMARY:Cancelled: Colloquium with Eske Willerslev (Director of CAEG at the University of Copenhagen\, DK)
DESCRIPTION:THE COLLOQUIUM WILL BE RESCHEDULED IN 2026! \n  \nOn 25 November we will welcome Eske Willerslev as a speaker at the SNP2Prot Colloquium Series. In Copenhagen\, he leads the Centre of excellence in Ancient Environmental Genomics (CAEG) and the Ancient Environmental Genomics Initiative for Sustainability (AEGIS). He is a professor at both the University of Copenhagen and University of Cambridge. In addition\, he is Excellence Professor at Bremen University\, Germany. \nSpeaker: Eske Willerslev (Director of CAEG at the University of Copenhagen\, DK)\nTitle: The AEGIS project \nDate: Tuesday\, 25 November 2025\nTime: 5 pm\nLocation: Lecture hall E.02\, Theodor-Lieser-Strasse 9 (Heide Süd Campus)\, 06120 Halle (Saale) \n\nAbstract: The Ancient Environmental Genomics Initiative for Sustainability (AEGIS) \nClimate change poses a critical threat to human food security\, and its impacts are forecast by the IPCC to affect agricultural production across much of the globe\, putting a significant proportion of the world’s population at risk of food insecurity\, if not starvation.\nAlthough modern agricultural practices have built cropping systems that maximise yields in today’s climate\, these typically lack genetic and organismal diversity\, require intensive use of chemical fertilisers\, pesticides\, and heavy irrigation\, and have limited resilience to rapid climatic and environmental change. Attempts to meet the coming challenges of food insecurity and ensuring agricultural sustainability are further constrained by the genetically depleted staple crops\, the slow processes of conventional breeding and our poor understanding of organismal interactions and adaptations in both natural and agro-ecosystems. Yet each unique climate cycle\, coupled with human cultivation and plant domestication (starting ~12\,000 years ago)\, produced novel genetic and organismal configurations\, specific for all types of environments\, but not seen since. This has resulted in an almost – infinite number of past species adaptations and ecosystem responses to climate changes in a wide range of natural and human-modified settings. The great majority of the genetic information underpinning these adaptive responses has been lost through evolutionary change. However\, a rich record of those responses survives in the earth over many thousands and millions of years as ancient environmental DNA (eDNA). \nA single gram of sediment contains billions of DNA fragments and other ancient biomolecules\, providing a comprehensive record of the organisms that inhabited the local environment\, including fungi\, bacteria\, viruses\, wild and domesticated plants and animals – even in the complete absence of living organisms or fossil remains. Following analytical developments in eDNA over the last two decades – and concurrent rapid advances in the ability to technically modify crops and their ecosystems – it is in principle feasible to tap into this vast eDNA archive at scale to reliably retrieve genetic and organismal information from the past and use nature’s own solutions to climate change (across time and environments) as a means for improving future food sustainability. \nThis presentation is an introduction to a newly started large-scale project termed Ancient Environmental Genomics Initiative for Sustainability (AEGIS). The vision behind AEGIS is to build a more sustainable and secure food production system while also preserving biodiversity in cropping systems under climate change. To meet its vision\, the 18 institutions behind AEGIS will develop the essential science and methodology to use ancient eDNA – alongside other ancient and modern biomolecule-based approaches – to identify important organismal associations and genetic adaptations in natural and agro-ecosystems that will improve future food security under climate change. \n  \n\nIf you like to meet with the speaker\, please contact the host\, Alain Tissier. \n\nSee all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/ \nThe SNP2Prot Colloquium Series is integrated to the \n\nHalle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/\nIPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare\n\n\n 
URL:https://snp2prot.uni-halle.de/event/colloquium-with-eske-willerslev-director-of-caeg-at-the-university-of-copenhagen-dk/
LOCATION:Lecture hall E.02 (Heide Süd Campus)\, Theodor-Lieser-Strasse 9\, Halle (Saale)\, 06120
CATEGORIES:SNP2Prot Colloquia
ORGANIZER;CN="Alain Tissier":MAILTO:Alain.Tissier@ipb-halle.de
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