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X-WR-CALNAME:Plant Proteoform Diversity
X-ORIGINAL-URL:https://snp2prot.uni-halle.de
X-WR-CALDESC:Events for Plant Proteoform Diversity
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DTSTART;TZID=Europe/Berlin:20260505T123000
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SUMMARY:Colloquium with Andrea Mattevi (University of Pavia\, Italy)
DESCRIPTION:On 5 May 2026\, Andrea Mattevi (University of Pavia\, Italy) will present insights to his current research as part of the SNP2Prot Colloquium Series. \nSpeaker: Andrea Mattevi (University of Pavia\, Italy)\nTitle: The Enzymology of a Metabolon \nDate: Tuesday\, 5 May 2026\nTime: 12:30 pm\nLocation: Lecture hall (GHS) of Biochemistry\, Kurt-Mothes-Straße 3 (Weinberg Campus)\, 06120 Halle (Saale) \n\nAbstract: Coenzyme Q\, CoQ\, is an essential antioxidant ubiquitous in nature. CoQ biosynthesis in humans has thus far been attributed to ten different proteins with many coalescing into a large assembly coined the ‘COQ metabolon’. Metabolons are protein assemblies that channel substrates within a metabolic pathway\, however\, their general aptitude for enzymatic biocatalysis remains poorly understood and several CoQ biosynthetic steps\, including C1-decarboxylation and C1-hydroxylation steps\, remain enigmatic in our understanding. To elucidate the prerequisites for CoQ biosynthesis and moreover\, assess the physicochemical properties of the metabolon\, we sought out to construct the entire metabolon in vitro. We employed an innovative evolution-engineering approach rooted by ancestral sequence reconstruction\, in addition to spectrophotometric and biophysical assays\, and analytical techniques to monitor CoQ biosynthesis. Our findings suggest that metabolons possess heightened catalytic efficiency\, consist of an intricate and dynamic number of protein interactions\, and are overseen by chaperoning and organisational protein mitigators. \nAcknowledgement: ERC project MetaQ \nReferences:\nNicoll\, C.R.\, Alvigini\, L.\, Gottinger\, A. et al. In vitro construction of the COQ metabolon unveils the molecular determinants of coenzyme Q biosynthesis. Nat Catal 7\, 148–160 (2024).\nWang D\, Gottinger A\, et aI. Complete Enzyme Clustering Enhances Coenzyme Q Biosynthesis via Substrate Channeling. bioRxiv [Preprint]. 2025 28:2025.05.24.655883 \n\nIf you like to meet with the speaker\, please contact the host\, Milton T. Stubbs. \n\nSee all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/ \nThe SNP2Prot Colloquium Series is integrated to the \n\nHalle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/\nIPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare\n\n\n 
URL:https://snp2prot.uni-halle.de/event/colloquium-with-andrea-mattevi-university-of-pavia-italy/
LOCATION:Lecture hall (GHS) of Biochemistry (Weinberg Campus)\, Kurt-Mothes-Straße 3\, Halle (Saale\, 06120\, Germany
CATEGORIES:SNP2Prot Colloquia
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DTSTART;TZID=Europe/Berlin:20260512T170000
DTEND;TZID=Europe/Berlin:20260512T170000
DTSTAMP:20260630T062153
CREATED:20260220T105331Z
LAST-MODIFIED:20260512T093218Z
UID:2582-1778605200-1778605200@snp2prot.uni-halle.de
SUMMARY:Colloquium with Johannes Debler (CCDM\, Perth\, Australia)
DESCRIPTION:On 12 May 2026\, Johannes Debler (Centre for Crop and Disease Management\, Perth\, Australia) will present insights to his current research as part of the SNP2Prot Colloquium Series. \nSpeaker: Johannes Debler (CCDM\, Perth\, Australia)\nTitle: Strange New Elements – Silenced genes and rogue DNA in fungal plant pathogens \nDate: Tuesday\, 12 May 2026\nTime: 17:00 pm\nLocation:  Lecture hall E.02 (Heide Süd Campus)   Theodor-Lieser-Strasse 9\, Halle (Saale)  \n\nAbstract: Many plant pathogens survive by staying hidden from their host’s immune system\, but sometimes we can turn that stealth against them. \nWe recently identified a putative avirulence gene silenced by a MULE:MuDR transposon insertion in Ascochyta rabiei\, the causal agent of Ascochyta blight in chickpea. This silencing event may have conferred such a strong evolutionary advantage that it drove a lifestyle shift across the entire species\, reclassifying our understanding of this pathogen. \nBut that’s not all we found hiding. During genome assembly curation\, we stumbled across a mysterious 24 kb circular element carrying an unusual combination of genes. Present in both A. rabiei and A. lentis\, an expanded search has since identified it across 11 fungal plant pathogens separated by millions of years of evolution\, yet remaining strikingly conserved. \nWhat is it? We have no idea\, but it’s definitely not a moon. \n\nIf you like to meet with the speaker\, please contact the host\, Thorsten Langner. \n\nSee all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/ \nThe SNP2Prot Colloquium Series is integrated to the \n\nHalle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/\nIPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare\n\n\n 
URL:https://snp2prot.uni-halle.de/event/colloquium-with-johannes-debler-ccdm-perth-australia/
LOCATION:Lecture hall E.02 (Heide Süd Campus)\, Theodor-Lieser-Strasse 9\, Halle (Saale)\, 06120
CATEGORIES:SNP2Prot Colloquia
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