Positions available at SNP2Prot

SNP2Prot is currently recruiting postdoctoral and doctoral researchers for the first 45-months funding period starting in October 2024.

We offer an excellent scientific environment for interested scientists of different research fields: Plant Science, Protein Science and Computer Science
at contributing institutions in Germany:

  • Martin Luther University Halle-Wittenberg, Halle (Saale)
  • Leibniz Institute of Plant Biochemistry (IPB), Halle (Saale)
  • Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Gatersleben
  • Leipzig University, Leipzig

Each of the 17 projects of SNP2Prot is designed to combine expertise of two principal investigators (PIs) of complementary disciplines. This promising concept ensures that all candidates (PhD students and postdocs) benefit significantly from the interdisciplinary environment including scientific training in structural protein biochemistry, plant biology as well as computational science and bioinformatics and training of transferable skills. Furthermore, the unique and comprehensive mentoring is ideal to develop and actively realize individual career planning.

Take the opportunity and become part of the SNP2Prot team.

See all open positions here:

Detailed information on the offered position, the project and the PIs can be found under the respective links.

Project A02 - Functional proteoform variation in thermomorphogenesis master regulators
Postdoc position, TV-L E13, 100%
TASKS // Protein MS and MS data analysis, Establishment of in vivo XL-MS in plant systems
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Pharmacy
PI // Andrea Sinz
Job advertisement // Reg.-Nr. 5-5519/24-D

Project B02 - Allelic variation in the control of calcium-dependent protein kinase activity and function in plant-environment interactions
Postdoc position, TV-L E13, 100%

TASKS // Protein MS and MS data analysis, Establishment of in vivo XL-MS in plant systems
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Pharmacy
PI // Andrea Sinz
Job advertisement // Reg.-Nr. 5-5521/24-D

Project A01 - Structure-function analysis of NAC transcription factor proteoforms
PhD position, TV-L E13, 65%
TASKS // Protein NMR spectroscopy, Biophysical protein characterisations, Experimental handling of proteins
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Physics
PI // Jochen Balbach
Job advertisement // Reg.-Nr. 5-5501/24-D

Project A04 - Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
PhD position, TV-L E13, 65%
TASKS // Cryo-EM Imaging and Structural Modeling, Integration of Data and Model Development
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Panagiotis Kastritis
Job advertisement // Reg.-Nr. 5-5504/24-D

Project A05 - Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
PhD position, TV-L E13, 65%
TASKS // Computational design of interactions between protein and RNA/DNA uing artificial intelligence and structure-based design, Expressing and testing designed proteins in bacterial, insect and mammalian cell cultures, Evalution of designed proteins using protein-DNA/RNA-binding assays and together with the project
WORK PLACE // Leipzig University, Institute for Drug Discovery
PI // Clara T. Schoeder
Job advertisement // [RegNr. *]

Project B01 - Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
PhD position, TV-L E13, 65%
TASKS // Protein expression in E. coli or other systems, Enzyme activity assays and characterization of kinetic parameters, Determination of posttranslational modifications, Protein-protein binding assays, Protein-lipid binding assays
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Ingo Heilmann
Job advertisement // Reg.-Nr. 5-5506/24-D

Project B01 - Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
PhD position, TV-L E13, 65%
TASKS // Protein MS and MS data analysis, Establishment of in vivo XL-MS in plant systems
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Pharmacy
PI // Andrea Sinz
Job advertisement // Reg.-Nr. 5-5507/24-D

Project B03 - Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
PhD position, TV-L E13, 65%
TASKS // Transient and stable protein expression (E. coli, N. benthamiana, A. thaliana), Protein characterization (enzyme activity and conformational change), Fluorescence spectroscopy (in vitro and in vivo imaging), Mass spectrometry
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Biochemistry of Plant Interactions
PI // Tina Romeis
Job advertisement // 2024-06-03 - Project B03


Project B05 - Role of plant SRO proteoforms in tolerance to oxidative and salinity stress
PhD position, TV-L E13, 65%
TASKS // Protein purification, Biochemical and biophysical characterization of proteins, Protein crystallization and structural analysis
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Milton T. Stubbs
Job advertisement // Reg.-Nr. 5-5510/24-D

Project C01 - Climate-associated functional polymorphisms of terpene synthases in Arabidopsis thaliana
PhD position, TV-L E13, 65%
TASKS // High throughput screening, Protein expression in yeast, Biochemical characterization of enzymes, Analytics by gas chromatography, Site-directed mutagenesis, Directed evolution, Chemical synthesis
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Organic Chemistry
PI // Martin Weissenborn
Job advertisement // Reg.-Nr. 5-5512/24-D

Project C03 - Impact of natural LPR1 proteoforms on Fe-dependent phosphate sensing
PhD position, TV-L E13, 65%
TASKS // Protein purification, Biochemical and biophysical protein characterizations, Protein crystallization experiments and structural analyses
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Milton T. Stubbs
Job advertisement // Reg.-Nr. 5-5514/24-D

Project C04 - Function of mevalonate kinase proteoforms in the adaptation to specific climates
PhD position, TV-L E13, 65%
TASKS // Protein expression and purification, Enzymology, Immunoprecipitation, Targeted mutagenesis in Arabidopsis, Metabolite profiling, phenotyping
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Cell and Metabolic Biology
PI // Alain Tissier
Job advertisement // 2024-06-03 - Project C04

Project C04 - Function of mevalonate kinase proteoforms in the adaptation to specific climates
PhD position, TV-L E13, 65%
TASKS // Computational Modeling and Molecular Dynamics Simulations, Structural Analysis of proteoforms by Cryo-EM
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Panagiotis Kastritis
Job advertisement // Reg.-Nr. 5-5515/24-D

Project C05 - Impact of natural allelic variation on structure and function of the immune proteases SAP1 and SAP2
PhD position, TV-L E13, 65%
TASKS // Protein structural MS and MS data analysis, additional: Protein expression in E. coli and protein purification
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Pharmacy
PI // Christian Ihling
Job advertisement // Reg.-Nr. 5-5516/24-D

Project A02 - Functional proteoform variation in thermomorphogenesis master regulators
Postdoc position, TV-L E13, 100%
TASKS // Cloning and heterologous expression of plant proteins in E. coli, Molecular characterization of variant-/proteoform-specific protein-protein and protein-DNA interactions, Cross-linking mass spectrometry and characterization of liquid-liquid phase separation processes in cooperation with structural biochemists, Generation and phenotypic characterization of Arabidopsis complementation lines
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences
PI // Marcel Quint
Job advertisement // Reg.-Nr. 5-5518/24-D

Project A01 - Structure-function analysis of NAC transcription factor proteoforms
PhD position, TV-L E13, 65%
TASKS // Cloning and molecular characterization of TF proteoforms (in vitro protein expression, protein-DNA and protein-protein interaction assays, in vivo transactivation assays, gene expression analyses, etc.), Complementation of Arabidopsis mutants and phenotypic characterization, GHT-SELEX (in collab. with A03)
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences
PI // Carolin Delker
Job advertisement // Reg.-Nr. 5-5502/24-D


Project A04 - Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
PhD position, TV-L E13, 65%
TASKS // Molecular cytogenetic characterization of proteins via fluorescence immunolabelling, Quantitative analysis of chromosome structure, Analysing patterns of meiotic recombination
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences
PI // Steven Dreissig
Job advertisement // Reg.-Nr. 5-5503/24-D


Project A05 - Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
PhD position, TV-L E13, 65%
TASKS // Analysis of microRNA expression in Arabidopsis accession, Cloning expression constructs followed by protein expression in tobacco, In vitro reconstitution of microRNA processing complexes and activity assays
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biology
PI // Sascha Laubinger
Job advertisement // Reg.-Nr. 5-5505/24-D


Project B01 - Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
PhD position, TV-L E13, 65%
TASKS // Protein expression in E. coli or other systems, Enzyme activity assays and characterization of kinetic parameters, Determination of posttranslational modifications, Protein-protein binding assays, Protein-lipid binding assays
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Ingo Heilmann
Job advertisement // Reg.-Nr. 5-5506/24-D


Project B03 - Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
PhD position, TV-L E13, 65%
TASKS // Transient and stable protein expression (E. coli, N. benthamiana, A. thaliana), Protein characterization (enzyme activity and conformational change), Fluorescence spectroscopy (in vitro and in vivo imaging), Mass spectrometry
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Biochemistry of Plant Interactions
PI // Tina Romeis
Job advertisement // 2024-06-03 - Project B03


Project B03 - Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
PhD position, TV-L E13, 65%
TASKS // Calcium imaging, Electrophysiological ion channel analyses, Protein localization, Phenotypical analyses, Ionome analyses
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences
PI // Edgar Peiter
Job advertisement // Reg.-Nr. 5-5508/24-D


Project B04 - Impact of allelic variation in jasmonate repressors on proteoform structure, co-receptor assembly and plant performance
PhD position, TV-L E13, 65%
TASKS // Protein expression and purification from E. coli and insect cells, Protein activity and binding assays, Analysis of morphological and cellular phenotypes in Arabidopsis
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Molecular Signal Processing
PI // Debora Gasperini
Job advertisement // 2024-06-03 - Project B04


Project B05 - Role of plant SRO proteoforms in tolerance to oxidative and salinity stress
PhD position, TV-L E13, 65%
TASKS // Characterisation of Arabidopsis lines with respect to abiotic stress tolerance, confocal microscopy, protein-protein interaction assays (in vitro / in planta) WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Biochemistry of Plant Interactions
PI // Lennart Wirthmüller
Job advertisement // 2024-06-03 - Project B05


Project C01 - Climate-associated functional polymorphisms of terpene synthases in Arabidopsis thaliana
PhD position, TV-L E13, 65%
TASKS // Molecular genetic studies on the gene family of terpene synthases in Arabidopsis, Protein expression in bacteria, yeast, and Arabidopsis, Biochemical characterization of enzymes, Analytics by gas chromatography, Site-directed mutagenesis, Protein modeling and substrate docking, Modeling of reaction pathways
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Pharmacy
PI // Jörg Degenhardt
Job advertisement // Reg.-Nr. 5-5511/24-D


Project C02 - Relevance of natural allelic variation in YUCCA genes for proteoform modulation, local auxin biosynthesis and phenotypic variation in natural Arabidopsis accessions
PhD position, TV-L E13, 65%
TASKS // Gene cloning, Generation and assessment of transgenic Arabidopsis plants, Crossing, Cultivation and phenotyping of Arabidopsis on artificial media, Recombinant expression of proteins, Protein gel blot analysis, Confocal microscopy
WORK PLACE // Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) Gatersleben, Physiology and Cell Biology
PI // Nicolaus von Wirén
Job advertisement // RefNr. 32/05/24


Project C04 - Function of mevalonate kinase proteoforms in the adaptation to specific climates
PhD position, TV-L E13, 65%
TASKS // Protein expression and purification, Enzymology, Immunoprecipitation, Targeted mutagenesis in Arabidopsis, Metabolite profiling, phenotyping
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Cell and Metabolic Biology
PI // Alain Tissier
Job advertisement // 2024-06-03 - Project C04


Project C05 - Impact of natural allelic variation on structure and function of the immune proteases SAP1 and SAP2
PhD position, TV-L E13, 65%
TASKS // Protein expression and purification in E. coli and N. benthamiana, complementation of Arabidopsis mutants and phenotypic characterization (resistance to bacterial infection), biochemical characterization of proteases, antibacterial assays
WORK PLACE // Leibniz Institute for Plant Biochemistry (IPB) Halle, Receptor Biochemistry
PI // Mariana Schuster
Job advertisement // 2024-06-04 - Project C05

Project A03 - Mutation-sensitive prediction of transcription factor-DNA interactions in plants
Postdoc position, TV-L E13, 100%
TASKS // ::::::::::::::::::::
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Computer Science
PI // Ivo Grosse
Job advertisement // [RegNr. *]


Project A03 - Mutation-sensitive prediction of transcription factor-DNA interactions in plants
Postdoc position, TV-L E13, 100%
TASKS //:::::::::::::::::::::::::
WORK PLACE // Leipzig University, Institute for Drug Discovery
PI // Jens Meiler
Job advertisement // [RegNr. *]


Project D02 - Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation
Postdoc position, TV-L E13, 100%
TASKS // Construction of a Plant Pangenome Browser; Machine Learning; integration of various omics (DAP-seq, GHT-SELEX, ChIP-seq, RNA-seq) data and 3D protein structure structure data for elucidating SNP effects of proteoforms; analysis of orthology relationships
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Agricultural & Nutritional Sciences
PI // Marcel Quint and Ivo Große
Job advertisement // [RegNr. *]


Project A04 - Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
PhD position, TV-L E13, 65%
TASKS // Cryo-EM Imaging and Structural Modeling, Integration of Data and Model Development
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Panagiotis Kastritis
Job advertisement // Reg.-Nr. 5-5504/24-D


Project A05 - Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
PhD position, TV-L E13, 65%
TASKS // Computational design of interactions between protein and RNA/DNA uing artificial intelligence and structure-based design, Expressing and testing designed proteins in bacterial, insect and mammalian cell cultures, Evalution of designed proteins using protein-DNA/RNA-binding assays and together with the project
WORK PLACE // Leipzig University, Institute for Drug Discovery
PI // Clara T. Schoeder
Job advertisement // [RegNr. *]


Project C04 - Function of mevalonate kinase proteoforms in the adaptation to specific climates
PhD position, TV-L E13, 65%
TASKS // Computational Modeling and Molecular Dynamics Simulations, Structural Analysis of proteoforms by Cryo-EM
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Biochemistry and Biotechnology
PI // Panagiotis Kastritis
Job advertisement // Reg.-Nr. 5-5515/24-D


Project D01 - Modeling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era
PhD position, TV-L E13, 100%
TASKS // Molecular modeling with AlphaFold, Rosetta, Haddock; Scientific programming with Python, R, or another programming language; Development of machine learning / deep learning methods for mutation effect predictions; Programming of web-based protein modeling applications
WORK PLACE // Leipzig University, Institute for Drug Discovery
PI // Georg Künze
Job advertisement // [RegNr. *]


Project D02 - Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation
PhD position, TV-L E13, 100%
TASKS // Analysis of SNP properties using different measures and bioinformatics methods; Analysis and comparison of proteoforms based on SNP properties and additional measures and methods for pairwise sequence comparison; Design and implementation of ranking and prioritization methods on the level of individual SNPs and on the level of proteoforms
WORK PLACE // Martin Luther University Halle-Wittenberg, Institute of Computer Science
PI // Ivo Große
Job advertisement // Reg.-Nr. 5-5517/24-D

 

Apply here:

Web Application Form

The web application form allows the simultaneous application for three SNP2Prot projects of your individual preference.