Interdisciplinary Collaborative Research Centre at
Martin Luther University Halle-Wittenberg
Spokesperson: Prof. Dr. Marcel Quint
The major objective of SNP2Prot is to understand the translation of genome-encoded sequence variation to structural, mechanistic and functional proteoform diversity in plants.
Parallel sequencing of natural accessions in plant populations discovered a wealth of DNA sequence variation, which mainly include a particularly prominent type of sequence variant, known as single nucleotide polymorphism (SNP). Despite the extensive recognition of gene-trait relationships, our understanding of the effects of allelic variation on the function of a given specific proteoform, which is ultimately responsible for the translation of the genetic variation to the observed phenotypic variation, is still in its infancy. The major objective of SNP2Prot is to understand the translation of genome-encoded sequence variation to structural, mechanistic and functional proteoform diversity. In this CRC initiative, the close interdisciplinary collaboration between (molecular) plant research and protein research is prerequisite to elucidate and ultimately predict how a substantial part of naturally occurring genetic variation mechanistically translates into the manifestation of phenotypic traits.
Small Change, Big Impact
Even the smallest changes at the genetic level can cause altered proteins (proteoforms) to be produced. Proteoforms can function differently in plants, which in turn can have a major impact on the phenotype of the plant.
Interdisciplinary, cooperative and international
More than 70 scientists are collaborating across institutional and disciplinary boundaries to realize a common research vision, gain new insights and exploit synergies within the SNP2Prot team.
Explore our Regularly Updated Events
Discover a wide selection of regularly organised scientific lectures, colloquia, workshops, and more – accessible to researchers from SNP2Prot and participating institutions.
Next Event:
Excursion to the exhibition “Planetary Peasants” at Kunstmuseum Moritzburg
Date: 11.09.2025 15:00
Date: Thursday, 11 September 2025 Time: 3 pm – 5 pm Location: Kunstmuseum Moritzburg Halle (Saale), Friedemann-Bach-Platz 5, 06108 Halle (Saale) In 2025, the end of the German Peasants’ War ... Read more
Integrated Research Training Group (IRTG) - PROTEOFORuM
The SNP2Prot graduate programme PROTEOFORuM combines unique features (tailor-made scientific training, laboratory rotations and interdisciplinary mentoring) with established graduate programme modules (e.g., thesis advisory committees, transferrable skills training, etc.) to efficiently prepare doctoral candidates for project completion, timely graduation and future scientific careers.
The IRTG PROTEOFORuM provides an infrastructure that:
Promotes each ECR in their thesis work by expanding their individual skill set in all relevant disciplines.
Ensures efficient progress of the interdisciplinary projects.
Fosters interaction and collaboration among CRC individuals, groups and projects.
