Interdisciplinary Collaborative Research Centre at
Martin Luther University Halle-Wittenberg
Spokesperson: Prof. Dr. Marcel Quint
The major objective of SNP2Prot is to understand the translation of genome-encoded sequence variation to structural, mechanistic and functional proteoform diversity.
Parallel sequencing of natural accessions in plant populations discovered a wealth of DNA sequence variation, which mainly include a particularly prominent type of sequence variant, known as single nucleotide polymorphism (SNP). Despite the extensive recognition of gene-trait relationships, our understanding of the effects of allelic variation on the function of a given specific proteoform, which is ultimately responsible for the translation of the genetic variation to the observed phenotypic variation, is still in its infancy. The major objective of SNP2Prot is to understand the translation of genome-encoded sequence variation to structural, mechanistic and functional proteoform diversity. In this CRC initiative, the close interdisciplinary collaboration between (molecular) plant research and protein research is prerequisite to elucidate and ultimately predict how a substantial part of naturally occurring genetic variation mechanistically translates into the manifestation of phenotypic traits.
