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The Collaborative Research Centre CRC 1664 is funded by Deutsche Forschungsgemeinschaft (DFG) from Oct 2024 to Jun 2028
Plant Proteoform Diversity

Plant Proteoform Diversity

Bridging the gap from genetic to phenotypic variation

  • RESEARCH
    • Overview
    • Research Programme
    • Projects
      • Proteins interacting with nucleic acids
        • A01 // Structure-function analysis of NAC transcription factor proteoforms
        • A02 // Functional proteoform variation in thermomorphogenesis master regulators
        • A03 // Mutation-sensitive prediction of transcription factor-DNA interactions in plants
        • A04 // Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
        • A05 // Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
        • A06 // A06 – Functional significance of Argonaute 2 (AGO2) proteoforms in the antiviral response in Arabidopsis thaliana
      • Proteins involved in signalling pathways (upstream of transcription)
        • B01 // Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
        • B02 // Allelic variation in the control of calcium-dependent protein kinase activity and function in plant-environment interactions
        • B03 // Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
        • B04 // Impact of allelic variation in jasmonate repressors on proteoform structure, co-receptor assembly and plant performance
        • B05 // Role of plant SRO proteoforms in tolerance to oxidative and salinity stress
      • Proteins with enzymatic functions
        • C01 // Climate-associated functional polymorphisms of terpene synthases in Arabidopsis thaliana
        • C02 // Relevance of natural allelic variation in YUCCA genes for proteoform modulation, local auxin biosynthesis and phenotypic variation in natural Arabidopsis accessions
        • C03 // Impact of natural LPR1 proteoforms on Fe-dependent phosphate sensing
        • C04 // Function of mevalonate kinase proteoforms in the adaptation to specific climates
        • C05 // Impact of natural allelic variation on structure and function of the immune proteases SAP1 and SAP2
      • Genome- and proteome-wide future resources
        • D01 // Modeling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era
        • D02 // Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation
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News

IPK Journal: „Wir wollen die Black Box öffnen“

8 January, 20258 January, 2025 by Julia Grimmer

17 December 2024 Prof. Dr. Marcel Quint, the spokesperson of SNP2Prot, discusses the objectives, timetable, and significance of the recently approved, DFG-funded collaborative research centre ‘Plant Proteoform Diversity’ in an … Read more

Categories News, News and press publications

Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures

3 April, 20254 December, 2024 by Julia Grimmer

Celia G. Moya, Rafael Rodriguez, Carlos S. Perez, Hilda Garay, Julian Wiesent, Stefan Gröger, Yordanka Masforrol, Yasser Perera, Silvio E. Perea & Jochen Balbach International Journal of Peptide Research and … Read more

Categories 2024, News, Publications

Tracing the Evolutionary History of the Temperature-Sensing Prion-like Domain in EARLY FLOWERING 3 Highlights the Uniqueness of AtELF3

3 April, 202530 October, 2024 by Julia Grimmer

Zihao Zhu, Jana Trenner, Carolin Delker and Marcel Quint Molecular Biology and Evolution, Volume 41, Issue 10, October 2024, msae205, https://doi.org/10.1093/molbev/msae205 Abstract: Plants have evolved mechanisms to anticipate and adjust … Read more

Categories 2024, News, Publications

Bioeconomy News: “New SFB: Protein biochemistry meets plant research”

23 January, 202519 June, 2024 by Julia Grimmer

17 June 2024 https://biooekonomie.de/en/news/new-sfb-protein-biochemistry-meets-plant-research The German Research Foundation is funding a new Collaborative Research Centre at the University of Halle-Wittenberg. The focus is on mutations in the genetic material of … Read more

Categories News, News and press publications

MLU: “Neuer Sonderforschungsbereich stärkt MLU-Forschung zu Pflanzen und Proteinen”

23 January, 20253 June, 2024 by Julia Grimmer

31 May 2024 Nummer 072/2024: https://pressemitteilungen.pr.uni-halle.de Rund 12,5 Millionen Euro erhält die Martin-Luther-Universität Halle-Wittenberg (MLU) für ihre Protein- und Pflanzenforschung. Die Deutsche Forschungsgemeinschaft (DFG) bewilligt an der MLU den neuen … Read more

Categories News, News and press publications
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Next Event:

Spring/Summer School Planning Meeting

Date: 08.12.2025 12:00

On 8 December 2025, we’ll hold the first planning meeting for the upcoming SNP2Prot Spring/Summer School 2026. During this meeting, the ECRs of our consortium will join forces with the ... Read more

See all SNP2Prot events here: EVENTS

Latest Publication:

Tüting, C., Janson, K., Kammel, M., Ihling, C., Lorenz, J., Kyrilis, F. L., Hamdi, F., Erdmann, C., Sinz, A., Sawers, R. G., & Kastritis, P. L. (2025). Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport. Nature Communications, 16(1), 9476. https://doi.org/10.1038/s41467-025-65159-3 https://www.nature.com/articles/s41467-025-65159-3

See all SNP2Prot publications here: PUBLICATIONS

Excited to share the latest collaborative SNP2Prot publication! This work combines cryo-EM, cross-linking, and multi-scale approaches to uncover how pentameric channels function. Insights that reach far beyond plant science. 🌍 Congrats to all authors!

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