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The Collaborative Research Centre CRC 1664 is funded by Deutsche Forschungsgemeinschaft (DFG) from Oct 2024 to Jun 2028
Plant Proteoform Diversity

Plant Proteoform Diversity

Bridging the gap from genetic to phenotypic variation

  • RESEARCH
    • Overview
    • Research Programme
    • Projects
      • Proteins interacting with nucleic acids
        • A01 // Structure-function analysis of NAC transcription factor proteoforms
        • A02 // Functional proteoform variation in thermomorphogenesis master regulators
        • A03 // Mutation-sensitive prediction of transcription factor-DNA interactions in plants
        • A04 // Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
        • A05 // Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
        • A06 // A06 – Functional significance of Argonaute 2 (AGO2) proteoforms in the antiviral response in Arabidopsis thaliana
      • Proteins involved in signalling pathways (upstream of transcription)
        • B01 // Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
        • B02 // Allelic variation in the control of calcium-dependent protein kinase activity and function in plant-environment interactions
        • B03 // Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
        • B04 // Impact of allelic variation in jasmonate repressors on proteoform structure, co-receptor assembly and plant performance
        • B05 // Role of plant SRO proteoforms in tolerance to oxidative and salinity stress
      • Proteins with enzymatic functions
        • C01 // Climate-associated functional polymorphisms of terpene synthases in Arabidopsis thaliana
        • C02 // Relevance of natural allelic variation in YUCCA genes for proteoform modulation, local auxin biosynthesis and phenotypic variation in natural Arabidopsis accessions
        • C03 // Impact of natural LPR1 proteoforms on Fe-dependent phosphate sensing
        • C04 // Function of mevalonate kinase proteoforms in the adaptation to specific climates
        • C05 // Impact of natural allelic variation on structure and function of the immune proteases SAP1 and SAP2
      • Genome- and proteome-wide future resources
        • D01 // Modeling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era
        • D02 // Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation
    • Publications
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Publications

Form follows function – structural interplay between DCL1 and pri-miRNAs

17 September, 2025 by Julia Grimmer

Scholl, C. R., Grosch, L., Baradei, J., Kastritis, P. L., Schoeder, C. T., & Laubinger, S. JTrends in Plant Science. Advance online publication, https://doi.org/10.1016/j.tplants.2025.07.016 Published: 15 September 2025 Abstract: MicroRNAs (miRNAs) guide post-transcriptional gene silencing in plants and shape … Read more

Categories 2025, 2025, News, Publications

Sense and sensitivity – decoding calcium signalling across cellular, autocrine, paracrine and endocrine pathways in plant resilience

9 September, 2025 by Julia Grimmer

Lederer, S., Liese, A., Lee, J., & Romeis, T. Current Opinion in Plant Biology, 87, 102782. https://doi.org/10.1016/j.pbi.2025.102782 Available online: 30 August 2025 Abstract: Calcium (Ca2+) signalling plays a central role in plant immunity, as … Read more

Categories 2025, News, Publications

Manganese handling in plants: Advances in the mechanistic and functional understanding of transport pathways

2 July, 20252 July, 2025 by Julia Grimmer

Bastian Meier, Oriana Mariani & Edgar Peiter Quantitative Plant Biology, 6:e16, 1–11, https://dx.doi.org/10.1017/qpb.2025.10012 Published: 20 June 2025 Abstract: As the catalytic centre of the oxygen-evolving complex in photosystem II and … Read more

Categories 2025, News, Publications

Hacking the immune system: plant immune protease engineering for crop protection

3 April, 2025 by Julia Grimmer

Mariana Schuster, Alexander L. Ciattoni & Renier A. L. van der Hoorn Journal of Experimental Botany, eraf137, https://doi.org/10.1093/jxb/eraf137 Published: 28 March 2025 Abstract: Genome engineering technologies allow the generation of … Read more

Categories 2025, News, Publications

Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures

3 April, 20254 December, 2024 by Julia Grimmer

Celia G. Moya, Rafael Rodriguez, Carlos S. Perez, Hilda Garay, Julian Wiesent, Stefan Gröger, Yordanka Masforrol, Yasser Perera, Silvio E. Perea & Jochen Balbach International Journal of Peptide Research and … Read more

Categories 2024, News, Publications

Tracing the Evolutionary History of the Temperature-Sensing Prion-like Domain in EARLY FLOWERING 3 Highlights the Uniqueness of AtELF3

3 April, 202530 October, 2024 by Julia Grimmer

Zihao Zhu, Jana Trenner, Carolin Delker and Marcel Quint Molecular Biology and Evolution, Volume 41, Issue 10, October 2024, msae205, https://doi.org/10.1093/molbev/msae205 Abstract: Plants have evolved mechanisms to anticipate and adjust … Read more

Categories 2024, News, Publications

Next Event:

Seminar – Introduction to PyMOL

Date: 27.10.2025 12:00

On 27 October 2025, Christian Tüting will present scientific training introducing the molecular visualization system PyMOL. Trainer: Christian Tüting, Postdoc (project D01) Topic: Introduction to PyMOL (https://www.pymol.org/) Date: Monday, 27 ... Read more

See all SNP2Prot events here: EVENTS

Latest Publication:

Scholl, C. R., Grosch, L., Baradei, J., Kastritis, P. L., Schoeder, C. T., & Laubinger, S. (2025). Form follows function – structural interplay between DCL1 and pri-miRNAs. Trends in Plant Science. Advance online publication. https://doi.org/10.1016/j.tplants.2025.07.016

See all SNP2Prot publications here: PUBLICATIONS

🎉 SNP2Prot turns 1! 🎉 From SNPs to proteoforms, we've spent a year decoding plant protein diversity with 70+ scientists across disciplines. Thanks for following along, here’s to more discoveries ahead! 🌱🧬 #SNP2Prot #PlantScience @dfg.de

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