Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1

Machner, L., Shaikhqasem, A., Gruber, T., Hamdi, F., Breithaupt, C., Kniest, J., Wiebe, F., Lewitzky, M., Parthier, C., Kyrilis, F. L., Balbach, J., Kastritis, P. L., Feller, S. M., & Stubbs, M. T. Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1. Structure (London, England : 1993). Advance online publication. … Read more

Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport

Tüting, C., Janson, K., Kammel, M., Ihling, C., Lorenz, J., Kyrilis, F. L., Hamdi, F., Erdmann, C., Sinz, A., Sawers, R. G., & Kastritis, P. L. Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport. Nature Communications, 16(1), 9476. https://doi.org/10.1038/s41467-025-65159-3 Published: 27 October 2025 Abstract: FocA … Read more