Colloquium with Anne Claire Conibear (TU Wien, Austria)
On 18 November 2025, Anne Claire Conibear (TU Wien, Austria) will present insights to her current research as part of the SNP2Prot Colloquium Series.
Speaker: Anne Claire Conibear (TU Wien, Austria)
Title: Posttranslational Modifications of Disordered Proteins
Date: Tuesday, 18 November 2025
Time: 5 pm
Location: Lecture hall E.02, Theodor-Lieser-Strasse 9 (Heide Süd Campus), 06120 Halle (Saale)
Abstract: The conformational flexibility of intrinsically disordered proteins and protein regions (IDRs), and their accessibility to modifying enzymes make IDRs hot-spots for protein regulation by posttranslational modifications (PTMs). Such PTMs increase the complexity of the proteome and can have central roles in regulating protein function, location, interactions and degradation. Little is known, however, about how PTMs modulate the conformations and interactions of IDRs, as they typically occupy multiple conformational states, have promiscuous interactions, and are often removed or poorly represented in structural biology studies. In this presentation, I will discuss our work towards understanding how PTMs modulate the conformations and interactions of IDRs. Protein synthesis and semi-synthesis provides access to site-specifically modified variants of IDRs, such as the HMGN1 and Tau proteins, and disordered termini of Hsp90 and β-catenin. These protein variants enable us to study the precise effects of PTMs and cross-talk of multiple PTMs on conformational populations using NMR spectroscopy. With these examples, I aim to show how integrating chemical protein synthesis with structural biology of IDRs allows us to gain new insights into the effects of PTMs on the conformation, dynamics and regulation of IDRs.
References:
[1] Conibear, A. C., Nat. Rev. Chem. 4, 674-695 (2020).
[2] Niederacher, G., Urwin, D.; Dijkwel, Y., Tremethick, D. J., Rosengren, K. J., Becker, C. F. W., Conibear, A. C., RSC Chem. Biol. 2, 537-550 (2021).
[3] Iebed, D., Gökler, T., van Ingen, H., Conibear, A. C., ChemBioChem, 25, e20241023 (2024).
[4] Gajsek, O., Becker, C. F. W., Conibear, A. C., Chem. Eur. J. e202403676 (2024).
If you like to meet with the speaker, please contact the host, Clara Schoeder (Uni Leipzig).
See all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/
The SNP2Prot Colloquium Series is integrated to the
- Halle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/
- IPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare