Colloquium with Markus Geisler (University of Fribourg, CH)
On 9 December 2025, Markus Geisler (University of Fribourg, CH) will present insights to his current research as part of the SNP2Prot Colloquium Series.
Speaker: Markus Geisler (University of Fribourg, CH)
Title: Substrate specificity and evolution of plant hormone transporters
Date: Tuesday, 9 December 2025
Time: 12:30 pm
Location: Lecture hall (GHS) of Biochemistry, Kurt-Mothes-Straße 3 (Weinberg Campus), 06120 Halle (Saale)
Abstract: In plants, members of the B-subfamily of ABC (ATP-Binding Cassette) transporters (ABCBs) were shown to own an extraordinarily high substrate specificity for a few auxinic compounds. However, recently, several reports have challenged our current view on the reported high substrate specificity of plant ABCBs.
In my talk, I will present recent examples from my lab that are pointing to the concept that a single plant ABCB transporter can transport multiple, diverse substrates in vivo. For such an event, I suggest using the term “substrate multi-specificity” in contrast to what had been described for yeast and mammalian ABCs involved in multidrug resistance (MDR) phenomena. Putative advantages and regulatory mechanisms of substrate multi-specificity will be outlined.
Further, I will present an overview on the evolution of Auxin-Transporting ABCBs, so-called ATAs, and their master regulator, the FKBP42, TWISTED DWARF1 (TWD1). Our findings suggest that ATAs are the first auxin transporters but that regulation by FKBPs, such as TWD1, came much later in evolution.
If you like to meet with the speaker, please contact the host, Marcel Quint.
See all upcoming SNP2Prot colloquia listed here: https://snp2prot.uni-halle.de/events/category/colloquium/
The SNP2Prot Colloquium Series is integrated to the
- Halle Plant Science Colloquium (HPSC) – https://www.landw.uni-halle.de/prof/pflanzenernaehrung/hpsc/
- IPB Seminar Series – https://www.ipb-halle.de/forschung/symposien-und-kolloquien/vortraege/ipb-seminare