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Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1
Machner, L., Shaikhqasem, A., Gruber, T., Hamdi, F., Breithaupt, C., Kniest, J., Wiebe, F., Lewitzky, M., Parthier, C., Kyrilis, F. L., Balbach, J., Kastritis, P. L., Feller, S. M., & Stubbs, M. T. Mechanism of SHP2 activation by bis-Tyr-phosphorylated Gab1. Structure (London, England : 1993). Advance online publication. … Read more
Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals
Shaikhqasem, A., Hamdi, F., Machner, L., Parthier, C., Breithaupt, C., Kyrilis, F. L., Feller, S. M., Kastritis, P. L., & Stubbs, M. T. Strategies for mitigating radiation damage and improving data completeness in 3D electron diffraction of protein crystals. Acta Crystallographica. Section D, … Read more
Extended – Call for Proposals: CRC Start-up Funding
The CRC provides start-up funding in 2026 and 2027 to support researchers in developing and realizing their independent project ideas. We therefore encourage Postdocs, PhD students who are (associated) members … Read more
Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport
Tüting, C., Janson, K., Kammel, M., Ihling, C., Lorenz, J., Kyrilis, F. L., Hamdi, F., Erdmann, C., Sinz, A., Sawers, R. G., & Kastritis, P. L. Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport. Nature Communications, 16(1), 9476. https://doi.org/10.1038/s41467-025-65159-3 Published: 27 October 2025 Abstract: FocA … Read more
Form follows function – structural interplay between DCL1 and pri-miRNAs
Scholl, C. R., Grosch, L., Baradei, J., Kastritis, P. L., Schoeder, C. T., & Laubinger, S. JTrends in Plant Science. Advance online publication, https://doi.org/10.1016/j.tplants.2025.07.016 Published: 15 September 2025 Abstract: MicroRNAs (miRNAs) guide post-transcriptional gene silencing in plants and shape … Read more
Sense and sensitivity – decoding calcium signalling across cellular, autocrine, paracrine and endocrine pathways in plant resilience
Lederer, S., Liese, A., Lee, J., & Romeis, T. Current Opinion in Plant Biology, 87, 102782. https://doi.org/10.1016/j.pbi.2025.102782 Available online: 30 August 2025 Abstract: Calcium (Ca2+) signalling plays a central role in plant immunity, as … Read more
Manganese handling in plants: Advances in the mechanistic and functional understanding of transport pathways
Bastian Meier, Oriana Mariani & Edgar Peiter Quantitative Plant Biology, 6:e16, 1–11, https://dx.doi.org/10.1017/qpb.2025.10012 Published: 20 June 2025 Abstract: As the catalytic centre of the oxygen-evolving complex in photosystem II and … Read more
Hacking the immune system: plant immune protease engineering for crop protection
Mariana Schuster, Alexander L. Ciattoni & Renier A. L. van der Hoorn Journal of Experimental Botany, eraf137, https://doi.org/10.1093/jxb/eraf137 Published: 28 March 2025 Abstract: Genome engineering technologies allow the generation of … Read more
DFG Approves SPP on AI-Driven Protein Design (Speaker: Jens Meiler)
31 March 2025 The DFG has recently announced the establishment of eight new Schwerpunktprogramme (SPP), set to start in 2026, with a total funding of 55 million euros. In a … Read more
SNP2Prot Kick-off: A Promising Start!
On February 25 and 26, 2025, SNP2Prot members gathered at the Leibniz Institute of Plant Biochemistry (IPB) in Halle (Saale) for the kick-off symposium. It was only two days – … Read more
MLU: “Turbo für die Forschung: MLU erhält Millionenförderung für neues Kryo-Elektronenmikroskop”
30 January 2025 Nummer 008/2025: https://pressemitteilungen.pr.uni-halle.de Mit einem hochmodernen Kryo-Elektronenmikroskop stärkt die Martin-Luther-Universität Halle-Wittenberg (MLU) ihre Bio- und Polymerwissenschaften. Rund 9,2 Millionen Euro erhält die Universität für ein neues Hochleistungsmikroskop … Read more
Mitteldeutsche Zeitung MZ: “Das Puzzle der Pflanzenproteine”
7 January 2025 The regional daily newspaper Mitteldeutsche Zeitung reports about the importance and opportunities in plant sciences connected to the research of the Collaborative Research Centre (CRC) 1664 “Plant … Read more
IPK Journal: „Wir wollen die Black Box öffnen“
17 December 2024 Prof. Dr. Marcel Quint, the spokesperson of SNP2Prot, discusses the objectives, timetable, and significance of the recently approved, DFG-funded collaborative research centre ‘Plant Proteoform Diversity’ in an … Read more
Diastereomers of the Anticancer Peptide CIGB-300 with Altered β-Turn Structures
Celia G. Moya, Rafael Rodriguez, Carlos S. Perez, Hilda Garay, Julian Wiesent, Stefan Gröger, Yordanka Masforrol, Yasser Perera, Silvio E. Perea & Jochen Balbach International Journal of Peptide Research and … Read more
12 Dec // SNP2Prot Get-Together
On 12 December 2024, we’re organizing an event for all CRC members who already started their positions and the PIs to meet for a first casual and informal get-together at … Read more
Tracing the Evolutionary History of the Temperature-Sensing Prion-like Domain in EARLY FLOWERING 3 Highlights the Uniqueness of AtELF3
Zihao Zhu, Jana Trenner, Carolin Delker and Marcel Quint Molecular Biology and Evolution, Volume 41, Issue 10, October 2024, msae205, https://doi.org/10.1093/molbev/msae205 Abstract: Plants have evolved mechanisms to anticipate and adjust … Read more
Bioeconomy News: “New SFB: Protein biochemistry meets plant research”
17 June 2024 https://biooekonomie.de/en/news/new-sfb-protein-biochemistry-meets-plant-research The German Research Foundation is funding a new Collaborative Research Centre at the University of Halle-Wittenberg. The focus is on mutations in the genetic material of … Read more
MLU: “Neuer Sonderforschungsbereich stärkt MLU-Forschung zu Pflanzen und Proteinen”
31 May 2024 Nummer 072/2024: https://pressemitteilungen.pr.uni-halle.de Rund 12,5 Millionen Euro erhält die Martin-Luther-Universität Halle-Wittenberg (MLU) für ihre Protein- und Pflanzenforschung. Die Deutsche Forschungsgemeinschaft (DFG) bewilligt an der MLU den neuen … Read more