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The Collaborative Research Centre CRC 1664 is funded by Deutsche Forschungsgemeinschaft (DFG) from Oct 2024 to Jun 2028
Plant Proteoform Diversity

Plant Proteoform Diversity

Bridging the gap from genetic to phenotypic variation

  • RESEARCH
    • Overview
    • Research Programme
    • Projects
      • Proteins interacting with nucleic acids
        • A01 // Structure-function analysis of NAC transcription factor proteoforms
        • A02 // Functional proteoform variation in thermomorphogenesis master regulators
        • A03 // Mutation-sensitive prediction of transcription factor-DNA interactions in plants
        • A04 // Quantitative cytogenetic characterisation and structural analysis of REC8 proteoforms in plant meiosis
        • A05 // Targeting of function and structure of Arabidopsis dicing complex proteoforms on microRNA biogenesis
        • A06 // A06 – Functional significance of Argonaute 2 (AGO2) proteoforms in the antiviral response in Arabidopsis thaliana
      • Proteins involved in signalling pathways (upstream of transcription)
        • B01 // Natural allelic variation of PI4P 5-kinases modulating plasma membrane processes in plants
        • B02 // Allelic variation in the control of calcium-dependent protein kinase activity and function in plant-environment interactions
        • B03 // Allelic variation of a vacuolar cation channel modulating ion homeostasis and calcium signalling in plants
        • B04 // Impact of allelic variation in jasmonate repressors on proteoform structure, co-receptor assembly and plant performance
        • B05 // Role of plant SRO proteoforms in tolerance to oxidative and salinity stress
      • Proteins with enzymatic functions
        • C01 // Climate-associated functional polymorphisms of terpene synthases in Arabidopsis thaliana
        • C02 // Relevance of natural allelic variation in YUCCA genes for proteoform modulation, local auxin biosynthesis and phenotypic variation in natural Arabidopsis accessions
        • C03 // Impact of natural LPR1 proteoforms on Fe-dependent phosphate sensing
        • C04 // Function of mevalonate kinase proteoforms in the adaptation to specific climates
        • C05 // Impact of natural allelic variation on structure and function of the immune proteases SAP1 and SAP2
      • Genome- and proteome-wide future resources
        • D01 // Modeling, understanding, and predicting >2 million Arabidopsis proteoforms in the post-genomic era
        • D02 // Development of SNPstar 2.0 and computational prediction of putative proteoform candidates with high functional proteoform variation
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CONTACT

Send an e-mail to: info@snp2prot.uni-halle.de

Dr. Julia Grimmer
// Coordinator

julia.grimmer@landw.uni-halle.de
Tel: +49 (0) 345 55 22605

Room 1.11

Betty-Heimann-Straße 5
06120 Halle (Saale)

Prof. Dr. Marcel Quint
// Spokesperson

marcel-quint@landw.uni-halle.de
Tel: +49 (0) 345 55 22739

Room 1.14

Betty-Heimann-Straße 5
06120 Halle (Saale)

Next Event:

SNP2Prot Retreat 11/25

Date: 10.11.2025 08:00

Date: Monday & Tuesday, 10 & 11 November 2025 Time: 8 am – 5 pm Location: Hotel Kloster Nimbschen, Nimbschener Landstr. 1, 04668 Grimma Schedule: Download v251103 Register here! On ... Read more

See all SNP2Prot events here: EVENTS

Latest Publication:

Tüting, C., Janson, K., Kammel, M., Ihling, C., Lorenz, J., Kyrilis, F. L., Hamdi, F., Erdmann, C., Sinz, A., Sawers, R. G., & Kastritis, P. L. (2025). Conserved hydrophilic checkpoints tune FocA-mediated formate:H+ symport. Nature Communications, 16(1), 9476. https://doi.org/10.1038/s41467-025-65159-3 https://www.nature.com/articles/s41467-025-65159-3

See all SNP2Prot publications here: PUBLICATIONS

Excited to share the latest collaborative SNP2Prot publication! This work combines cryo-EM, cross-linking, and multi-scale approaches to uncover how pentameric channels function. Insights that reach far beyond plant science. 🌍 Congrats to all authors!

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